Platelets: The Chameleons Of Cancer Biology

James Michael, Thomas Jefferson University

Have you ever been in a classroom and wondered to yourself whether the information being presented could be wrong?

During graduate school, I audited a medical school class in which the professor remarked that at some point in the students’ medical training, a fact would be presented that later may be shown to be incorrect.

New discoveries are continuously upending our most fundamentally held dogmas. One area currently being reexamined is the complicated interactions between the components of blood with your body. Don’t worry; just like your high school textbook says, red blood cells still bring oxygen from the lungs to rest of the body, and white blood cells are still protecting your body from foreign invaders. However, the more subtle roles of blood, especially in diseases like cancer, are not fully understood.

I am a cell and molecular biologist, and my background in research began with studying changes within cells that cause cancer. My interest in cancer eventually led me to explore how tumors are supplied with adequate nutrition. One blood component continued to arise in literature, displaying an interesting and dynamic role after a person develops cancer: platelets.

Platelets and cancer

Platelets are the component of blood that springs into action when you get a paper cut or scrape your knee. The signals governing the recognition of a wound, and how to address healing, are quite complicated. However, under normal physiological conditions, these signals mediate a process called platelet activation, which results in healing the wound by closing broken blood vessels.

In addition to this well-known role, scientists have uncovered many other functions of platelets. In fact, an association between higher numbers of platelets and the progression of cancer has been recognized for nearly five decades. Platelet numbers are elevated in cancer patients, and studies have shown that platelet-mediated blood clots are associated with tumor cell metastasis. That suggests that platelets may be linked to the spread of cancer to other parts of the body. But that may not be the only thing the platelets do for cancer.

Platelets, along with other cell types, release microparticles which respond to a variety of stimuli, including those which mediate platelet activation for wound healing.

While the mechanisms of microparticles are not completely understood, several studies have demonstrated they contain molecules that modulate which genes are turned on and off. Altering gene activity ultimately affects the production or turnover of proteins, which can cause a multitude of changes that affect health. Interestingly, microparticles contain molecules that have been shown to alter gene expression, and are associated with cancer progression. That brings up an interesting question: Is it possible that platelets and the microparticles they release upon activation could also modulate cancer progression?

Do platelets drive cancer?

My colleagues and I sought to address this, beginning with perhaps the most important question: whether platelet-derived microparticles were detectable in patient cancer tissue. Indeed, using a high-resolution microscope we observed microparticles in cancers from many tissue types.

Importantly, we did not see microparticles in normal tissue from the same patient, indicating they were specifically targeting cancer cells. This was a particularly interesting observation, because until then, these vesicle-like structures were hypothesized to affect only other cells within the blood vessel, and not target any other surrounding cells. Our team demonstrated that platelet-derived microparticles specifically target tumors.

Moreover, those targeted cells absorbed the gene-regulating molecules within the microparticles. However, contrary to our original hypothesis, we observed that microparticles inhibited solid tumor growth. This finding showed that platelets may not be so easy to pick on as only a bad guy in cancer progression.

Rethinking the role of platelets

New information has enabled researchers like myself to reevaluate our understanding of the role of platelets in cancer. Until recently, relatively few studies have observed a protective role of platelets in cancer.

While there is substantial evidence linking intact platelets to promoting cancer, the dual pro- and anti-cancerous roles of platelets raise some fascinating questions about both intact platelets and the microparticles that they release. In this way, it is tempting to consider platelets as so-called chameleons within the realm of cancer biology. The intact platelets appear to promote cancer progression, but the microparticles do the opposite, creating a natural check-and-balance system.

Further, the so-called leaky nature of tumor blood vessels has been posited as a likely reason for microparticles to have access to cancerous, but not normal, tissue. It is enticing to consider that someday, with a bit more characterization regarding the cargo being transferred, scientists could utilize the body’s natural delivery of extracellular vesicles, like these microparticles, as a therapeutic resource.The Conversation

James Michael, Lecturer of Biochemistry, Thomas Jefferson University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Avatar
THE CONVERSATIONhttps://theconversation.com/us
THE CONVERSATION US launched as a pilot project in October 2014. It is an independent source of news and views from the academic and research community, delivered direct to the public. Our team of professional editors work with university and research institute experts to unlock their knowledge for use by the wider public. We aim to help rebuild trust in journalism. All authors and editors sign up to our Editorial Charter. All contributors must abide by our Community Standards policy. We only allow authors to write on a subject on which they have proven expertise, which they must disclose alongside their article. Authors’ funding and potential conflicts of interest must also be disclosed. Failure to do so carries a risk of being banned from contributing to the site. The Conversation started in Melbourne Victoria and the innovative technology platform and development team is based in the university and research precinct of Carlton. Our newsroom is based in Boston but our team is part of a global newsroom able to share content across sites and around the world. The Conversation US is a non-profit educational entity.​
avatar
  Subscribe  
Notify of

JUST ONE CLICK HERE TO GET YOUR DAILY DOSE

REAL PEOPLE

Powerful voices from around the globe that speak to our shared human experience. May they inspire you and give you great hope.

JUST 1 CLICK

IS ALL IT TAKES TO LEARN SOMETHING NEW TODAY

Must Read

Your Emotions Can Get in the Way of Your Confidence

There is a distinction between self-confidence and self-esteem for a reason; many people confuse the two. Self-confidence and self-esteem are different from each other. Self-confidence...

JUST 1 CLICK

IS ALL IT TAKES TO BEGIN ENJOYING OUR PODCASTS

JUST 1 CLICK

IS ALL IT TAKES TO EXPLORE OUR INSPIRING GLOBAL COMMUNITIES